GPB SCIENTIFIC

The capabilities of the deterministic lateral displacement (DLD) technology has been well published

GPB Scientific DLD technology, both alone and in combination with magnetic separation, has been described in a range of peer-reviewed journal articles and posters, which are linked below.

Sample Prep for Flow Cytometry

  1. Automated Leukocyte Processing by Microfluidic Deterministic Lateral Displacement [Cytometry Part A, 89A: 1073-1083, 2016]
  2. Sample Preparation for Flow Cytometry Benefits From Some Lateral Thinking [Cytometry Part A, 89A: 1054-1056, 2016]

Size + Magnetic Separation

  1. DLD Microfluidic Purification and Characterization of Intact and Viable Circulating Tumor Cells in Peripheral Blood [AACR Poster April 2016]
  2. Automated Processing of Human Blood Leukocytes by a Plastic Disposable Microfluidic Deterministic Lateral Displacement Device [CYTO Poster June 2016]

Size-based selection

  1. Continuous particle separation through deterministic lateral displacement [Science 2004; 304:987-990]
  2. Deterministic hydrodynamics: Taking blood apart [Proc Nat Acad Sci 2008; 103:14779-14784]
  3. A microfluidics approach for the isolation of nucleated red blood cells (NRBCs) from the peripheral blood of pregnant women [Prenat Diagn 2008; 28:892-899]
  4. Crossing microfluidic streamlines to lyse, label and wash cells [Lab Chip 2008; 8:1448-53]
  5. Improved Performance of Deterministic Lateral Displacement Arrays with Triangular Posts [Microfluidics and Nanofluidics 9, pp. 1143-1149 (2010)]
  6. Deterministic separation of cancer cells from blood at 10 mL/min [AIP Advances 2, 042107-1-7 (2012)]
  7. Inhibition of clot formation in deterministic lateral displacement arrays for processing large volumes of blood for rare cell capture [Lab Chip 2015, 10.1039/c4lc01409j (MAR 2015)]

Affinity-capture

  1. Isolation of rare circulating tumour cells in cancer patients by microchip technology [Nature 2007; 450:1235-1239]
  2. Detection of mutations in EGFR in circulating lung-cancer cells [N Engl J Med 2008; 359:366-77]