The capabilities of the deterministic lateral displacement (DLD) technology have been well published

GPB Scientific DLD technology, both alone and in combination with magnetic separation, has been described in a range of peer-reviewed journal articles and posters, which are linked below.


Sample Prep for Flow Cytometry

  1. Automated Leukocyte Processing by Microfluidic Deterministic Lateral Displacement [Cytometry Part A, 89A: 1073-1083, 2016]
  2. Sample Preparation for Flow Cytometry Benefits From Some Lateral Thinking [Cytometry Part A, 89A: 1054-1056, 2016]


Cell-Based Therapies

  1. Deterministic Lateral Displacement - The next generation of CAR-T cell processing? [SLAS TECHNOLOGY: Translating Life Sciences Innovation Jan 23, 2018]


Size + Magnetic Separation

  1. DLD Microfluidic Purification and Characterization of Intact and Viable Circulating Tumor Cells in Peripheral Blood [AACR Poster April 2016]
  2. Automated Processing of Human Blood Leukocytes by a Plastic Disposable Microfluidic Deterministic Lateral Displacement Device [CYTO Poster June 2016]


Size-based selection

  1. Continuous particle separation through deterministic lateral displacement [Science 2004; 304:987-990]
  2. Deterministic hydrodynamics: Taking blood apart [Proc Nat Acad Sci 2008; 103:14779-14784]
  3. A microfluidics approach for the isolation of nucleated red blood cells (NRBCs) from the peripheral blood of pregnant women [Prenat Diagn 2008; 28:892-899]
  4. Crossing microfluidic streamlines to lyse, label and wash cells [Lab Chip 2008; 8:1448-53]
  5. Improved Performance of Deterministic Lateral Displacement Arrays with Triangular Posts [Microfluidics and Nanofluidics 9, pp. 1143-1149 (2010)]
  6. Deterministic separation of cancer cells from blood at 10 mL/min [AIP Advances 2, 042107-1-7 (2012)]
  7. Inhibition of clot formation in deterministic lateral displacement arrays for processing large volumes of blood for rare cell capture [Lab Chip 2015, 10.1039/c4lc01409j (MAR 2015)]



  1. Isolation of rare circulating tumour cells in cancer patients by microchip technology [Nature 2007; 450:1235-1239]
  2. Detection of mutations in EGFR in circulating lung-cancer cells [N Engl J Med 2008; 359:366-77]